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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton

CO2 + H2O → H+ + HCO3-

Reactome: R-HSA-1237045
Compartment: extracellular region
Rhea: RHEA:10750

Inputs

CO2CHEBI:16526, CO2, extracellular region
H2OCHEBI:15377, H2O, extracellular region

Outputs

H+CHEBI:15378, H, extracellular region
HCO3-CHEBI:17544, CHO3, extracellular region

Catalysed by

carbonate dehydratase activity of CA6:Zinc [extracellular region]EC 4.2.1.1

Literature

Gustin from human parotid saliva is carbonic anhydrase VI Biochem Biophys Res Commun, 1998
Carbonic anhydrase activators: the first activation study of the human secretory isoform VI with amino acids and amines Bioorg Med Chem, 2007
Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors J Med Chem, 2007
Structure and mechanism of carbonic anhydrase Pharmacol Ther, 1997