Source assertion

PDBe/SIFTS maps PDB 3ML5 to UniProt P43166 with chain-level identity and coverage retained.

Evidence ID: STRUCTURE:PDB:3ML5:UNIPROT:P43166
Subject dossier: ca7
Source chain: uniprot + pdbe
Upstream record: 3ML5
Corpus snapshot: 2026-07-14T09:23:31Z
Admission status: In this release

Experimental structure

Crystal structure of the C183S/C217S mutant of human CA VII in complex with acetazolamide

PDB ID: 3ML5
Experimental method: X-ray diffraction
Resolution: %!f(*float64=0x2eca05fee860) Å
SIFTS identifier: CAH7_HUMAN
Deposited: 20100416
Released / revised: 20110302 / 20241009

Chain-level mapping

Entity	Chain	Structural asym	Identity	Coverage	UniProt range
1	`A`	`A`	99.0%	100.0%	1–264

Experimental constructs

Entity	Chains / asym IDs	Molecule	Length	Mutation flag	Preparation
1	A / A	Carbonic anhydrase 7polypeptide(L)	269 residues	C183S, C217S	Genetically manipulated

Reading this structure

This is an experimentally determined structure, not a predicted model. A co-crystallised ligand, if any, does not by itself show binding affinity. The structure says nothing about kinetics, pathway rate or metabolic flux.

Snapshot provenance

Each row is a source snapshot this record was built from: when it was retrieved, its path and SHA-256 digest, and the exact request. The snapshot files stay with the build and are not served here. These rows document this record; they are not general citations.

Retrieved	Snapshot	SHA-256	Upstream request
2026-07-14T09:21:32Z	`raw/uniprot/entries/P43166.json`	`dc0ec23dc5d7dfcf4737e905d75df89f664cdb3e05519fcfef79fbaf218da84f`	Open exact source
2026-07-14T09:21:58Z	`raw/pdbe/mappings/3ml5.json`	`2ef3a24a608d2bc54c1ff780b6f4903b4582cfaaad18f6c2fe3ad10fa2b32ca6`	Open exact source
2026-07-14T09:22:14Z	`raw/pdbe/summary/chunk-02.json`	`79ac3fb4e9e30c8c858b4d8ed8bbe6f85e8e0d0e3630627a999691f40a3d330d`	Open exact source
2026-07-14T09:22:14Z	`raw/pdbe/experiment/chunk-02.json`	`e42f681713cd9cdce851cc48738b3c6e0f0c075d0006a640c484bcab84561898`	Open exact source
2026-07-14T09:22:15Z	`raw/pdbe/molecules/chunk-02.json`	`27833f4d4cb9a9bfcb110f6e551fe2a5ccef01ccea4dda947132af6c51bd66e6`	Open exact source