Source assertion
ChEMBL direct single-protein activity record with source-reported and source-standardized lexical values preserved.
Lossless activity measurement
- Source-reported value
- = 5.7 nM
- Source-standardized value
- = 5.7 nM
- Reported endpoint
- Kinact
- Standardized endpoint
- Kinact
- Reported upper bound
- not reported by the source
- Reported text value
- not reported by the source
- Standardization flag
- 0
- pChEMBL from source
- not reported by the source
Reported and source-standardized fields are displayed separately and retain their exact lexical values. The standardized field does not overwrite the upstream report.
No cross-assay comparison is authorized by this record. Evaluate target, construct, endpoint, relation, units, assay format, conditions, and exact molecular form first.
The protein is classified as an acatalytic relative of the family. This ChEMBL activity stays in the release as a source-reported measurement, but it does not reclassify the protein as catalytic, and it is not ranked against catalytic family members.
Assay and target
- ChEMBL activity
1980545- Target
CHEMBL2420, SINGLE PROTEIN- Assay
CHEMBL897979, Binding (B)- BAO format
BAO_0000357, single protein format- BAO endpoint
BAO_0000179- Target confidence
- 9, Direct single protein target assigned
- Source quality flags
- potential_duplicate=0; data_validity_comment=not reported by the source
Inhibition of cloned catalytic domani of human carbonic anhydrase 11 by CO2 hydration stopped-flow assay
Compound identity
- Molecule
CHEMBL20, ACETAZOLAMIDE- Parent form
CHEMBL20; is_parent_form=true- Molecule type
- Small molecule
- Chirality source code
- 2
- Standard InChIKey
BZKPWHYZMXOIDC-UHFFFAOYSA-N- Canonical SMILES
CC(=O)Nc1nnc(S(N)(=O)=O)s1- Standard InChI
InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
Document
Colinas PA, Bravo RD, Vullo D, Scozzafava A, Supuran CT.
- ChEMBL document
CHEMBL1149682- Journal / year
- Bioorg Med Chem Lett, 2007
- PubMed
- 17658252
Comparison state
- Prequalified
- No — pairwise evaluation is still required
- Protein identity
- O75493, taxon 9606
- Variant / construct
- not reported by the source / not reported by the source
- Conditions
- pH not reported by the source; temperature not reported by the source °C; substrate not reported by the source; buffer not reported by the source
Snapshot provenance
Each row is a source snapshot this record was built from: when it was retrieved, its path and SHA-256 digest, and the exact request. The snapshot files stay with the build and are not served here. These rows document this record; they are not general citations.
| Retrieved | Snapshot | SHA-256 | Upstream request |
|---|---|---|---|
| 2026-07-14T09:21:33Z | raw/uniprot/entries/O75493.json | 1c27d284e17a666e94656536119b00789c29f98abb86ee46caf2abcdba8a01c0 | Open exact source |
| 2026-07-14T09:22:20Z | raw/chembl/targets/CHEMBL2420.json | 3b55a351a51ea152bc923f22a2c49d02ffbd89b2057015c5cdb57de2c826ba59 | Open exact source |
| 2026-07-14T09:22:42Z | raw/chembl/direct-assays/CHEMBL2420.json | a214f4d8db9b267940d0b2ce7bad920c51e2193c0bd5c90ce20eed5015514428 | Open exact source |
| 2026-07-14T09:23:08Z | raw/chembl/assay-activities/CHEMBL897979.json | 1ee7404bf0524b827df0b5af537c316c17ec0880688d28114111c7afe7fa3f4f | Open exact source |
| 2026-07-14T09:23:28Z | raw/chembl/activities/1980545.json | f272febeb41355ff59a5b338fcdf4082acb5820c2a8f7eb491cc3de1538dbb06 | Open exact source |
| 2026-07-14T09:23:27Z | raw/chembl/assays/CHEMBL897979.json | 32955cfc0b54529d37f16b61b9f6d82d48c41b055aeccb724ec8992c929e55e0 | Open exact source |
| 2026-07-14T09:23:20Z | raw/chembl/molecules/CHEMBL20.json | 6b07a8754aad1e0e3a2ad71a185215a21d0c942143f77e80555dd6d7fe39df19 | Open exact source |
| 2026-07-14T09:23:28Z | raw/chembl/documents/CHEMBL1149682.json | d46206b0244bc757f6eced38e6c63296bf64b20e3d8ab9e1babb747bfb6170dd | Open exact source |