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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · Metabolism
Data

CA11 · ChEMBL activity 1980545

Kinact source measurement: = 5.7 nM. No cross-assay comparison is prequalified.

Assay activity1980545In this release

Source assertion

ChEMBL direct single-protein activity record with source-reported and source-standardized lexical values preserved.
Evidence ID
ACTIVITY:ChEMBL_37:1980545
Subject dossier
ca11
Source chain
uniprot + chembl
Upstream record
1980545
Corpus snapshot
2026-07-14T09:23:31Z
Admission status
In this release

Lossless activity measurement

Source-reported value
= 5.7 nM
Source-standardized value
= 5.7 nM
Reported endpoint
Kinact
Standardized endpoint
Kinact
Reported upper bound
not reported by the source
Reported text value
not reported by the source
Standardization flag
0
pChEMBL from source
not reported by the source

Reported and source-standardized fields are displayed separately and retain their exact lexical values. The standardized field does not overwrite the upstream report.

Not comparable with other recordsCATALYTIC_STATUS_MISMATCH, CONDITION_MISSING

No cross-assay comparison is authorized by this record. Evaluate target, construct, endpoint, relation, units, assay format, conditions, and exact molecular form first.

Catalytic status

The protein is classified as an acatalytic relative of the family. This ChEMBL activity stays in the release as a source-reported measurement, but it does not reclassify the protein as catalytic, and it is not ranked against catalytic family members.

Assay and target

ChEMBL activity
1980545
Target
CHEMBL2420, SINGLE PROTEIN
Assay
CHEMBL897979, Binding (B)
BAO format
BAO_0000357, single protein format
BAO endpoint
BAO_0000179
Target confidence
9, Direct single protein target assigned
Source quality flags
potential_duplicate=0; data_validity_comment=not reported by the source
Upstream assay description

Inhibition of cloned catalytic domani of human carbonic anhydrase 11 by CO2 hydration stopped-flow assay

Compound identity

Molecule
CHEMBL20, ACETAZOLAMIDE
Parent form
CHEMBL20; is_parent_form=true
Molecule type
Small molecule
Chirality source code
2
Standard InChIKey
BZKPWHYZMXOIDC-UHFFFAOYSA-N
Canonical SMILES
CC(=O)Nc1nnc(S(N)(=O)=O)s1
Standard InChI
InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)

Document

Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I and II, and extracellular isoforms IV, IX, and XII with sulfamides incorporating sugar moieties.

Colinas PA, Bravo RD, Vullo D, Scozzafava A, Supuran CT.

ChEMBL document
CHEMBL1149682
Journal / year
Bioorg Med Chem Lett, 2007
PubMed
17658252

Comparison state

Prequalified
No — pairwise evaluation is still required
Protein identity
O75493, taxon 9606
Variant / construct
not reported by the source / not reported by the source
Conditions
pH not reported by the source; temperature not reported by the source °C; substrate not reported by the source; buffer not reported by the source

Snapshot provenance

Each row is a source snapshot this record was built from: when it was retrieved, its path and SHA-256 digest, and the exact request. The snapshot files stay with the build and are not served here. These rows document this record; they are not general citations.

RetrievedSnapshotSHA-256Upstream request
2026-07-14T09:21:33Zraw/uniprot/entries/O75493.json1c27d284e17a666e94656536119b00789c29f98abb86ee46caf2abcdba8a01c0Open exact source
2026-07-14T09:22:20Zraw/chembl/targets/CHEMBL2420.json3b55a351a51ea152bc923f22a2c49d02ffbd89b2057015c5cdb57de2c826ba59Open exact source
2026-07-14T09:22:42Zraw/chembl/direct-assays/CHEMBL2420.jsona214f4d8db9b267940d0b2ce7bad920c51e2193c0bd5c90ce20eed5015514428Open exact source
2026-07-14T09:23:08Zraw/chembl/assay-activities/CHEMBL897979.json1ee7404bf0524b827df0b5af537c316c17ec0880688d28114111c7afe7fa3f4fOpen exact source
2026-07-14T09:23:28Zraw/chembl/activities/1980545.jsonf272febeb41355ff59a5b338fcdf4082acb5820c2a8f7eb491cc3de1538dbb06Open exact source
2026-07-14T09:23:27Zraw/chembl/assays/CHEMBL897979.json32955cfc0b54529d37f16b61b9f6d82d48c41b055aeccb724ec8992c929e55e0Open exact source
2026-07-14T09:23:20Zraw/chembl/molecules/CHEMBL20.json6b07a8754aad1e0e3a2ad71a185215a21d0c942143f77e80555dd6d7fe39df19Open exact source
2026-07-14T09:23:28Zraw/chembl/documents/CHEMBL1149682.jsond46206b0244bc757f6eced38e6c63296bf64b20e3d8ab9e1babb747bfb6170ddOpen exact source