UniProt-reviewed mitochondrial alpha-carbonic-anhydrase scope record. The pathway map shows its reaction context without making tissue, rate or flux claims. This release links 3 source records to this accession, a selection rather than every record the upstream databases hold.
Normalized identity
- Gene
- CA5A
- UniProt accession
P35218- Catalytic status
- Catalytic
- Review state
- UniProt-reviewed
- Taxon
- 9606
- Entry version
- 197, updated 2026-06-10
- Sequence identity
- v1, CRC64
C4E998D269AB1FE5 - Sequence length
- 305 residues
- Selected structures
- 0
- Selected activities
- 2
- Reaction assignments
- 1
- ChEMBL targets
- CHEMBL4789
Where the identity data came from
Each row is a UniProt snapshot used to build this release: when it was retrieved, its SHA-256 digest and the exact request. The snapshot files stay with the build and are not served here.
| Retrieved | Build-input snapshot | SHA-256 | Upstream request |
|---|---|---|---|
| 2026-07-14T09:21:32Z | raw/uniprot/entries/P35218.json | 3daaace95b24bb2a3505bfc3dc00d69a45a868bef35d44db5ad2f62660d4ce94 | Open exact source |
Source-reported location comments
- Mitochondrion
UniProt function text
Mitochondrial carbonic anhydrase that catalyzes the reversible conversion of carbon dioxide to bicarbonate/HCO3 (PubMed:24530203, PubMed:8356065). Mitochondria are impermeable to HCO3, and thus this intramitochondrial carbonic anhydrase is pivotal in providing HCO3 for multiple mitochondrial enzymes that catalyze the formation of essential metabolites of intermediary metabolism in the urea and Krebs cycles (PubMed:24530203)