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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GLYAT transfers ISB to glycine

ISB-CoA + Gly → CoA-SH + ISB-Gly + H+

Reactome: R-HSA-9971621
Compartment: mitochondrial matrix
Rhea: RHEA:19870

Inputs

ISB-CoACHEBI:57338, C25H38N7O17P3S, mitochondrial matrix
GlyCHEBI:57305, C2H5NO2, mitochondrial matrix

Outputs

CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
ISB-GlyCHEBI:133610, C6H10NO3, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

glycine N-acyltransferase activity of GLYAT [mitochondrial matrix]EC 2.3.1.13; UniProt Q6IB77

Literature

Acyl-CoA: glycine N-acyltransferase: in vitro studies on the glycine conjugation of straight- and branched-chained acyl-CoA esters in human liver Biochem Med Metab Biol, 1986