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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

OTC gene expression

OTC gene → OTC precursor

Reactome: R-HSA-9959881
Compartment: cytoplasm · nucleoplasm
Rhea: None recorded

Inputs

OTC geneR-HSA-9959831, nucleoplasm

Outputs

OTC precursorR-HSA-9956408, cytosol

Literature

p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis Nature, 2019
Human ornithine decarboxylase paralogue (ODCp) is an antizyme inhibitor but not an arginine decarboxylase Biochem J, 2008
A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane Biochem J, 2007
Polyamines in cancer: integrating organismal metabolism and antitumour immunity Nat Rev Cancer, 2022