CERT1-2 transfers CERA from the ER membrane to the Golgi membrane

CERA → CERA

Reactome

R-HSA-9956909

Compartment

Golgi membrane · endoplasmic reticulum membrane

Rhea

None recorded

Catalysed by

• ceramide transfer activity of CERT1-2:PPM1L:VAPA/B dimer [endoplasmic reticulum membrane]

Literature

1. Oxysterol-binding Protein Activation at Endoplasmic Reticulum-Golgi Contact Sites Reorganizes Phosphatidylinositol 4-Phosphate Pools J Biol Chem, 2016
2. Molecular machinery for non-vesicular trafficking of ceramide Nature, 2003
3. Efficient trafficking of ceramide from the endoplasmic reticulum to the Golgi apparatus requires a VAMP-associated protein-interacting FFAT motif of CERT J Biol Chem, 2006
4. Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide Proc Natl Acad Sci U S A, 2008
5. Structure, functions and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites FEBS Lett, 2019
6. Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network Biochim Biophys Acta, 2012