Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SIRT5 desuccinylates CPS1

NAD+ + H2O + N6-succinyl K1291 CPS1 → NAM + 2''-O-succinyl-ADP-D-ribose(3-) + CPS1

Reactome: R-HSA-9955518
Compartment: mitochondrial matrix
Rhea: RHEA:47669

Inputs

NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix
H2OCHEBI:15377, H2O, mitochondrial matrix
N6-succinyl K1291 CPS1R-HSA-9955506, mitochondrial matrix

Outputs

NAMCHEBI:17154, C6H6N2O, mitochondrial matrix
2''-O-succinyl-ADP-D-ribose(3-)CHEBI:87832, C19H24N5O17P2, mitochondrial matrix
CPS1R-HSA-70544, mitochondrial matrix

Catalysed by

protein-succinyllysine desuccinylase activity of SIRT5 [mitochondrial matrix]UniProt Q9NXA8

SIRT5 desuccinylates CPS1

Inputs

Outputs

Catalysed by

Literature