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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SIRT5 deglutarylates CPS1

N6-glutaryl lysine CPS1 + 8 NAD+ + 8 H2O → CPS1 + 8 2''-O-glutaryl-ADP-D-ribose(3-) + 8 NAM

Reactome: R-HSA-9955504
Compartment: mitochondrial matrix
Rhea: RHEA:47665

Inputs

N6-glutaryl lysine CPS1R-HSA-9955510, mitochondrial matrix
8 NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix
8 H2OCHEBI:15377, H2O, mitochondrial matrix

Outputs

CPS1R-HSA-70544, mitochondrial matrix
8 2''-O-glutaryl-ADP-D-ribose(3-)CHEBI:87829, C20H26N5O17P2, mitochondrial matrix
8 NAMCHEBI:17154, C6H6N2O, mitochondrial matrix

Catalysed by

protein-glutaryllysine deglutarylase activity of SIRT5 [mitochondrial matrix]UniProt Q9NXA8

Literature

Lysine glutarylation is a protein posttranslational modification regulated by SIRT5 Cell Metab, 2014