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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CHST15 transfers sulfate to (6-)GalNAc-4-sulfate

PAPS + D4S-PGs → PAP + H+ + D4,6S-PGs

Reactome: R-HSA-9941312
Compartment: Golgi membrane · Golgi lumen
Rhea: RHEA:54301

Inputs

PAPSCHEBI:58339, C10H11N5O13P2S, Golgi lumen
D4S-PGsR-HSA-2065135, Golgi lumen

Outputs

PAPCHEBI:58343, C10H11N5O10P2, Golgi lumen
H+CHEBI:15378, H, Golgi lumen
D4,6S-PGsR-HSA-9941241, Golgi lumen

Catalysed by

N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity of CHST15 [Golgi membrane]EC 2.8.2.33; UniProt Q7LFX5

Literature

A unique nonreducing terminal modification of chondroitin sulfate by N-acetylgalactosamine 4-sulfate 6-o-sulfotransferase J Biol Chem, 2003