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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ROS/RNS degrade HA

ROS,RNS + HA → HA + (HA)50

Reactome: R-HSA-9941244
Compartment: extracellular region
Rhea: None recorded

Inputs

ROS,RNSR-ALL-9941221, extracellular region
HAR-ALL-2160848, extracellular region

Outputs

HAR-ALL-2160848, extracellular region
(HA)50R-ALL-2160894, plasma membrane

Literature

Degradative action of reactive oxygen species on hyaluronan Biomacromolecules, 2006
Roles of Proteoglycans and Glycosaminoglycans in Wound Healing and Fibrosis Int J Cell Biol, 2015