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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PXYLP1 dephosphorylates Xyl moiety

GlcA-Gal-Gal-XylP-proteins + H2O → GlcA-Gal-Gal-Xyl-proteins + Pi

Reactome: R-HSA-9940993
Compartment: Golgi lumen
Rhea: RHEA:56513

Inputs

GlcA-Gal-Gal-XylP-proteinsR-HSA-9941158, Golgi lumen
H2OCHEBI:15377, H2O, Golgi lumen

Outputs

GlcA-Gal-Gal-Xyl-proteinsR-HSA-2064225, Golgi lumen
PiCHEBI:43474, HO4P, Golgi lumen

Catalysed by

phosphatase activity of PXYLP1 [Golgi membrane]EC 3.1.3; UniProt Q8TE99

Literature

Chondroitin sulfate metabolism in the brain Acta Neurobiol Exp (Wars), 2019
Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans J Biol Chem, 2014