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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

DBT transfers BCAA to CoA

BCAA-lipoH2-K105-DBT + CoA-SH → BCAA-CoAs + LipoH2-K105-DBT

Reactome: R-HSA-9859163
Compartment: mitochondrial matrix
Rhea: RHEA:18867

Inputs

BCAA-lipoH2-K105-DBTR-HSA-9859149, mitochondrial matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix

Outputs

BCAA-CoAsR-ALL-508261, mitochondrial matrix
LipoH2-K105-DBTR-HSA-9859167, mitochondrial matrix

Catalysed by

acyltransferase activity, transferring groups other than amino-acyl groups of BCKDH [mitochondrial matrix]EC 2.3.1

Literature

Genomic and biochemical analysis of repeatedly observed variants in DBT in individuals with maple syrup urine disease of Central American ancestry Am J Med Genet A, 2022