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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Unknown dehydrogenase oxidizes 4-HBz

4-Hbz + H2O + NAD+ → PHB + NADH + H+

Reactome: R-HSA-9856794
Compartment: mitochondrial matrix
Rhea: RHEA:20306

Inputs

4-HbzCHEBI:17597, C7H6O2, mitochondrial matrix
H2OCHEBI:15377, H2O, mitochondrial matrix
NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix

Outputs

PHBCHEBI:17879, C7H5O3, mitochondrial matrix
NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

4-hydroxybenzaldehyde dehydrogenase (NAD+) activity of Unknown dehydrogenase [mitochondrial matrix]EC 1.2.1.64

Literature

Mechanistic Details of Early Steps in Coenzyme Q Biosynthesis Pathway in Yeast Cell Chem Biol, 2016
Mitochondrial protein functions elucidated by multi-omic mass spectrometry profiling Nat Biotechnol, 2016