SDHA:SDHB binds to SDHC:SDHD
FAD-SDHA:SDHB:2Fe-2S:3Fe-4S:4Fe-4S:SDHFA1:SDHFA3 + SDHC:SDHD:heme b → SDH complex + SDHAF1 + SDHAF3
- Reactome
- R-HSA-9855252
- Compartment
- mitochondrial inner membrane · mitochondrial matrix
- Rhea
- None recorded
Inputs
- FAD-SDHA:SDHB:2Fe-2S:3Fe-4S:4Fe-4S:SDHFA1:SDHFA3R-HSA-9855213, mitochondrial matrix
- SDHC:SDHD:heme bR-HSA-9853501, mitochondrial inner membrane
Outputs
- SDH complexR-HSA-70990, mitochondrial inner membrane
- SDHAF1R-HSA-9854988, mitochondrial matrix
- SDHAF3R-HSA-9855015, mitochondrial matrix
Literature
- Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes Essays Biochem, 2018
- Protein-mediated assembly of succinate dehydrogenase and its cofactors Crit Rev Biochem Mol Biol, 2015
- Flavinylation and assembly of succinate dehydrogenase are dependent on the C-terminal tail of the flavoprotein subunit J Biol Chem, 2012
- Mutations in the heme b-binding residue of SDHC inhibit assembly of respiratory chain complex II in mammalian cells Mitochondrion, 2009