Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SDHA binds to SDHB

FAD-SDHA:SDHAF4 + SDHB:2Fe-2S:3Fe-4S:4Fe-4S:SDHAF1:SDHAF3 → SDHAF4 + FAD-SDHA:SDHB:2Fe-2S:3Fe-4S:4Fe-4S:SDHFA1:SDHFA3

Reactome: R-HSA-9855212
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

FAD-SDHA:SDHAF4R-HSA-9854960, mitochondrial matrix
SDHB:2Fe-2S:3Fe-4S:4Fe-4S:SDHAF1:SDHAF3R-HSA-9854993, mitochondrial matrix

Outputs

SDHAF4R-HSA-9854972, mitochondrial matrix
FAD-SDHA:SDHB:2Fe-2S:3Fe-4S:4Fe-4S:SDHFA1:SDHFA3R-HSA-9855213, mitochondrial matrix

Catalysed by

protein folding chaperone activity of SDHAF4 [mitochondrial matrix]UniProt Q5VUM1

Literature

Protein-mediated assembly of succinate dehydrogenase and its cofactors Crit Rev Biochem Mol Biol, 2015
The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase Cell Metab, 2014