SIRT3 deacetylates AcK-IDH2 dimer
2 NAD+ + AcK-IDH2 dimer → 2 NAM + 2 2'-O-acetyl-ADP-ribose + IDH2 dimer
- Reactome
- R-HSA-9854463
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:43636
Inputs
- 2 NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix
- AcK-IDH2 dimerR-HSA-9854462, mitochondrial matrix
Outputs
- 2 NAMCHEBI:17154, C6H6N2O, mitochondrial matrix
- 2 2'-O-acetyl-ADP-riboseCHEBI:83767, C17H23N5O15P2, mitochondrial matrix
- IDH2 dimerR-HSA-450982, mitochondrial matrix
Catalysed by
- NAD-dependent protein lysine deacetylase activity of SIRT3(?-399):Zn2+ [mitochondrial matrix]EC 2.3.1.286
Literature
- Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation Mol. Cell. Biol., 2007
- SIRT3 protein deacetylates isocitrate dehydrogenase 2 (IDH2) and regulates mitochondrial redox status J Biol Chem, 2012
- Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells Mol Cell, 2021
- Sirtuin-3-Mediated Cellular Metabolism Links Cardiovascular Remodeling with Hypertension Biology (Basel), 2023