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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ACAT1 tetramer acetylates IDH2 dimer

2 Ac-CoA + IDH2 dimer → 2 CoA-SH + 2 H+ + AcK-IDH2 dimer

Reactome: R-HSA-9854415
Compartment: mitochondrial matrix
Rhea: RHEA:45948

Inputs

2 Ac-CoACHEBI:57288, C23H34N7O17P3S, mitochondrial matrix
IDH2 dimerR-HSA-450982, mitochondrial matrix

Outputs

2 CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
2 H+CHEBI:15378, H, mitochondrial matrix
AcK-IDH2 dimerR-HSA-9854462, mitochondrial matrix

Catalysed by

acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]EC 2.3.1

Literature

Regulation of cellular metabolism by protein lysine acetylation Science, 2010
Lysine acetylation restricts mutant IDH2 activity to optimize transformation in AML cells Mol Cell, 2021