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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Frataxin transfers Fe2+ to ACO2

ACO2:3Fe-4S + 2 Iron:FXN → ACO2:4Fe-4S + FXN(81-210) + Fe2+

Reactome: R-HSA-9854405
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

ACO2:3Fe-4SR-HSA-9854373, mitochondrial matrix
2 Iron:FXNR-HSA-1362402, mitochondrial matrix

Outputs

ACO2:4Fe-4SR-HSA-9854344, mitochondrial matrix
FXN(81-210)R-HSA-1362390, mitochondrial matrix
Fe2+CHEBI:29033, Fe, mitochondrial matrix

Catalysed by

iron chaperone activity of 2 Iron:FXN [mitochondrial matrix]

Literature

Redox sensitive human mitochondrial aconitase and its interaction with frataxin: In vitro and in silico studies confirm that it takes two to tango Free Radic Biol Med, 2023
Frataxin acts as an iron chaperone protein to modulate mitochondrial aconitase activity Science, 2004
Friedreich's ataxia: point mutations and clinical presentation of compound heterozygotes Ann Neurol, 1999