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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ROS,RNS oxidize ACO2:4Fe-4S

ROS,RNS + ACO2:4Fe-4S → ACO2:3Fe-4S + Fe2+

Reactome: R-HSA-9854368
Compartment: mitochondrial matrix
Rhea: None recorded

Inputs

ROS,RNSR-ALL-9854374, mitochondrial matrix
ACO2:4Fe-4SR-HSA-9854344, mitochondrial matrix

Outputs

ACO2:3Fe-4SR-HSA-9854373, mitochondrial matrix
Fe2+CHEBI:29033, Fe, mitochondrial matrix

Catalysed by

molecular sensor activity of ACO2:4Fe-4S [mitochondrial matrix]

Literature

Inactivation-reactivation of aconitase in Escherichia coli. A sensitive measure of superoxide radical J Biol Chem, 1992
Mitochondrial aconitase reaction with nitric oxide, S-nitrosoglutathione, and peroxynitrite: mechanisms and relative contributions to aconitase inactivation Free Radic Biol Med, 2007
Aconitase as Iron-Sulfur Protein, Enzyme, and Iron-Regulatory Protein Chem Rev, 1996