CSKMT methylates Citrate Synthase
Methylated(n) CS dimer + 2 S-adenosyl-L-methionine → Methylated(n+1) CS dimer + 2 H+ + 2 S-adenosyl-L-homocysteine
- Reactome
- R-HSA-9854315
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:55544, RHEA:55548, RHEA:55552
Inputs
- Methylated(n) CS dimerR-HSA-9854325, mitochondrial matrix
- 2 S-adenosyl-L-methionineCHEBI:59789, C15H23N6O5S, mitochondrial matrix
Outputs
- Methylated(n+1) CS dimerR-HSA-9854313, mitochondrial matrix
- 2 H+CHEBI:15378, H, mitochondrial matrix
- 2 S-adenosyl-L-homocysteineCHEBI:57856, C14H20N6O5S, mitochondrial matrix
Catalysed by
- protein-lysine N-methyltransferase activity of CSKMT [mitochondrial matrix]EC 2.1.1; UniProt A8MUP2
Literature
- Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation J Biol Chem, 2017
- Human METTL12 is a mitochondrial methyltransferase that modifies citrate synthase FEBS Lett, 2017
- Methyltransferase-like proteins in cancer biology and potential therapeutic targeting J Hematol Oncol, 2023