DLST transfers succinyl to CoA
CoA-SH + SuccinyllipoH2-K110-DLST → SUCC-CoA + LipoH2-K110-DLST
- Reactome
- R-HSA-9853512
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:15215
Inputs
- CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
- SuccinyllipoH2-K110-DLSTR-HSA-9853502, mitochondrial matrix
Outputs
- SUCC-CoACHEBI:57292, C25H35N7O19P3S, mitochondrial matrix
- LipoH2-K110-DLSTR-HSA-9853485, mitochondrial matrix
Catalysed by
- dihydrolipoyllysine-residue succinyltransferase activity of OGDH complex [mitochondrial matrix]EC 2.3.1.61
Literature
- Structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate dehydrogenase complex (hKGDHc) revealed by cryo-EM and cross-linking mass spectrometry: Implications for the overall hKGDHc structure Biochim Biophys Acta Gen Subj, 2021
- Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas Am J Hum Genet, 2019
- Isolation, characterization and structural organization of the gene and pseudogene for the dihydrolipoamide succinyltransferase component of the human 2-oxoglutarate dehydrogenase complex Eur J Biochem, 1994