B4GALT5/6 transfer Gal to GlcCer
UDP-Gal + GlcCer → UDP + H+ + LacCer-d18
- Reactome
- R-HSA-9851347
- Compartment
- Golgi membrane · Golgi lumen
- Rhea
- RHEA:31495
Inputs
- UDP-GalCHEBI:66914, C15H22N2O17P2, Golgi lumen
- GlcCerCHEBI:22801, C25H46NO8R, Golgi membrane
Outputs
- UDPCHEBI:58223, C9H11N2O12P2, Golgi lumen
- H+CHEBI:15378, H, Golgi lumen
- LacCer-d18CHEBI:17950, C31H56NO13R, Golgi membrane
Catalysed by
- UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity of B4GALT5/6 [Golgi membrane]EC 2.4.1.274
Literature
- Establishment of HeLa cell mutants deficient in sphingolipid-related genes using TALENs PLoS One, 2014
- Convergence: Lactosylceramide-Centric Signaling Pathways Induce Inflammation, Oxidative Stress, and Other Phenotypic Outcomes Int J Mol Sci, 2021
- β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5 Glycobiology, 2013