ST8SIA5 transfers Neu5Ac to gangliosides
CMP-Neu5Ac + GM1b,GD1a,GD3,GT1b → CMP + GQ1b,GT3,GD1c,GT1a + H+
- Reactome
- R-HSA-9845587
- Compartment
- Golgi membrane · Golgi lumen
- Rhea
- None recorded
Inputs
- CMP-Neu5AcCHEBI:57812, C20H29N4O16P, Golgi lumen
- GM1b,GD1a,GD3,GT1bR-ALL-9845581, Golgi membrane
Outputs
- CMPCHEBI:60377, C9H12N3O8P, Golgi lumen
- GQ1b,GT3,GD1c,GT1aR-ALL-9845591, Golgi membrane
- H+CHEBI:15378, H, Golgi lumen
Catalysed by
- alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity of ST8SIA5 [Golgi membrane]EC 2.4.3.8; UniProt O15466
Literature
- Molecular cloning and expression of human alpha2,8-sialyltransferase (hST8Sia V) Biochem. Biophys. Res. Commun., 1997
- Molecular cloning and expression of a fifth type of alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and GT3 J Biol Chem, 1996
- Analysis of biochemical features of ST8 α-N-acetyl-neuraminide α2,8-sialyltransferase (St8sia) 5 isoforms Glycoconj J, 2022