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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ST3GAL2,3 transfer Neu5Ac to gangliosides

CMP-Neu5Ac + GM1,GD1b,GA1 → CMP + GD1a,GM1b,GT1b + H+

Reactome: R-HSA-9845538
Compartment: Golgi membrane · Golgi lumen
Rhea: RHEA:47572

Inputs

CMP-Neu5AcCHEBI:57812, C20H29N4O16P, Golgi lumen
GM1,GD1b,GA1R-ALL-9845510, Golgi membrane

Outputs

CMPCHEBI:60377, C9H12N3O8P, Golgi lumen
GD1a,GM1b,GT1bR-ALL-9845541, Golgi membrane
H+CHEBI:15378, H, Golgi lumen

Catalysed by

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity of ST3GAL2,3 [Golgi membrane]EC 2.4.3.4

Literature

Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II) Biochem Biophys Res Commun, 1996
Biosynthesis of the major brain gangliosides GD1a and GT1b Glycobiology, 2012
Phenotype of ST3GAL3 deficient patients: A case and review of the literature Eur J Med Genet, 2021
Cloning and sequencing of nineteen transcript isoforms of the human alpha2,3-sialyltransferase gene, ST3Gal III; its genomic organisation and expression in human tissues Glycoconj J, 2002