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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

B3GALT4 transfers Gal to gangliosides

GM2,GD2,GA2 + UDP-Gal → GM1,GD1b,GA1 + UDP + H+

Reactome: R-HSA-9845516
Compartment: Golgi membrane · Golgi lumen
Rhea: None recorded

Inputs

GM2,GD2,GA2R-ALL-9845519, Golgi membrane
UDP-GalCHEBI:66914, C15H22N2O17P2, Golgi lumen

Outputs

GM1,GD1b,GA1R-ALL-9845510, Golgi membrane
UDPCHEBI:58223, C9H11N2O12P2, Golgi lumen
H+CHEBI:15378, H, Golgi lumen

Catalysed by

N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase activity of B3GALT4 [Golgi membrane]EC 2.4.1.86; UniProt O96024

Literature

A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family J Biol Chem, 1998
The galactosyltransferase family Cell. Mol. Life Sci., 2002