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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ST3GAL5 transfers NeuNAc to ceramides

LacCer/GalCer/GA1/GA2 + CMP-Neu5Ac → GM1/2/3/4 + CMP + H+

Reactome: R-HSA-9844860
Compartment: Golgi membrane · Golgi lumen
Rhea: RHEA:41776

Inputs

LacCer/GalCer/GA1/GA2R-ALL-9844855, Golgi membrane
CMP-Neu5AcCHEBI:57812, C20H29N4O16P, Golgi lumen

Outputs

GM1/2/3/4R-ALL-9844871, Golgi membrane
CMPCHEBI:60377, C9H12N3O8P, Golgi lumen
H+CHEBI:15378, H, Golgi lumen

Catalysed by

beta-galactoside (CMP) alpha-2,3-sialyltransferase activity of ST3GAL5 [Golgi membrane]EC 2.4.3.4; UniProt Q9UNP4

Literature

Expression cloning and functional characterization of human cDNA for ganglioside GM3 synthase J. Biol. Chem., 1998
Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance Adv. Cancer Res., 2013
Human GM3 synthase: a new mRNA variant encodes an NH2-terminal extended form of the protein Biochim Biophys Acta, 2006
Evidence supporting a late Golgi location for lactosylceramide to ganglioside GM3 conversion Glycobiology, 2000
Molecular identification, tissue distribution and subcellular localization of mST3GalV/GM3 synthase Glycobiology, 2000
Ganglioside GM3 Synthase Deficiency in Mouse Models and Human Patients Int J Mol Sci, 2022