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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ABCC1,ABCG2 transport C18-S1P to extracellular region

C18-S1P + ATP + H2O → C18-S1P + ADP + H+ + Pi

Reactome: R-HSA-9843721
Compartment: cytosol · plasma membrane · extracellular region
Rhea: RHEA:38951

Inputs

C18-S1PCHEBI:60119, C18H37NO5P, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

C18-S1PCHEBI:60119, C18H37NO5P, extracellular region
ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol
PiCHEBI:43474, HO4P, cytosol

Catalysed by

sphingolipid intramembrane carrier activity of ABCC1,ABCG2 [plasma membrane]

Literature

Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2 J Biol Chem, 2010
Role of ABCC1 in export of sphingosine-1-phosphate from mast cells Proc Natl Acad Sci U S A, 2006
Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone J Mol Med (Berl), 2009