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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PSAP(195-273) dimer binds PE

PSAP(195-273) dimer + PE 30,32,34 → PSAP(195-273):PE

Reactome: R-HSA-9842115
Compartment: lysosomal lumen · multivesicular body, internal vesicle membrane
Rhea: None recorded

Inputs

PSAP(195-273) dimerR-HSA-9840482, lysosomal lumen
PE 30,32,34R-ALL-9840942, multivesicular body, internal vesicle membrane

Outputs

PSAP(195-273):PER-HSA-9842117, lysosomal lumen

Catalysed by

phosphatidylethanolamine binding activity of PSAP(195-273) dimer [lysosomal lumen]

Literature

Crystal structure of saposin B reveals a dimeric shell for lipid binding Proc Natl Acad Sci U S A, 2003