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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ARSA removes sulfate from SM3

SM3 + H2O → LacCer + SO4(2-)

Reactome: R-HSA-9840949
Compartment: lysosomal lumen
Rhea: None recorded

Inputs

SM3CHEBI:90163, C16H26NO16SR2, lysosomal lumen
H2OCHEBI:15377, H2O, lysosomal lumen

Outputs

LacCerCHEBI:195546, C16H27NO13R2, lysosomal lumen
SO4(2-)CHEBI:16189, O4S, lysosomal lumen

Catalysed by

cerebroside-sulfatase activity of active ARSA:Ca2+ [lysosomal lumen]EC 3.1.6.8

Literature

Characterization of urinary sulfatides in metachromatic leukodystrophy using electrospray ionization-tandem mass spectrometry Mol Genet Metab, 2001
Human urinary sulfatides in patients with sulfatidosis (metachromatic leukodystrophy) J Lipid Res, 1971