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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

bHEXA,bHEXS hydrolyze GM2A:SM2

GM2A:SM2 + H2O → GalNAc + SM3 + GM2A(32-193)

Reactome: R-HSA-9840884
Compartment: lysosomal lumen
Rhea: None recorded

Inputs

GM2A:SM2R-HSA-9840882, lysosomal lumen
H2OCHEBI:15377, H2O, lysosomal lumen

Outputs

GalNAcCHEBI:28037, C8H15NO6, lysosomal lumen
SM3CHEBI:90163, C16H26NO16SR2, lysosomal lumen
GM2A(32-193)R-HSA-1605614, lysosomal lumen

Catalysed by

beta-N-acetylhexosaminidase activity of bHEXA,bHEXS [lysosomal lumen]EC 3.2.1.52

Literature

Physiological substrates for human lysosomal beta -hexosaminidase S J Biol Chem, 2002