PSAP(195-273) dimer:PE binds and mobilizes ligands

PSAP(195-273):PE + PSAP(195-273) ligands → PSAP(195-273):Ligands:PE

Reactome

R-HSA-9840470

Compartment

lysosomal lumen · multivesicular body, internal vesicle membrane

Rhea

None recorded

Catalysed by

• sphingolipid activator protein activity of PSAP(195-273) dimer [lysosomal lumen]

Literature

1. Degradation of membrane-bound ganglioside GM1. Stimulation by bis(monoacylglycero)phosphate and the activator proteins SAP-B and GM2-AP J Biol Chem, 2000
2. Crystal structure of saposin B reveals a dimeric shell for lipid binding Proc Natl Acad Sci U S A, 2003
3. Glycosphingolipid specificity of the human sulfatide activator protein Eur J Biochem, 1991
4. Emerging concepts of ganglioside metabolism FEBS Lett, 2018