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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PSAP is cleaved

PSAP → PSAP(195-273) + PSAP(311-391) + PSAP(405-486) + PSAP(60-142)

Reactome: R-HSA-9840334
Compartment: lysosomal lumen · lysosomal membrane
Rhea: None recorded

Inputs

PSAPR-HSA-9840325, lysosomal lumen

Outputs

PSAP(195-273)R-HSA-9840336, lysosomal lumen
PSAP(311-391)R-HSA-1605602, lysosomal membrane
PSAP(405-486)R-HSA-9840328, lysosomal lumen
PSAP(60-142)R-HSA-351333, lysosomal lumen

Literature

Lipid-binding proteins in membrane digestion, antigen presentation, and antimicrobial defense J Biol Chem, 2005
A Comparative Study of Human Saposins Molecules, 2018
Molecular role of sulfated glycoprotein-1 (SGP-1/prosaposin) in Sertoli cells Histol Histopathol, 1995
Saposin proteins: structure, function, and role in human lysosomal storage disorders FASEB J, 1991
Lysosomal degradation of membrane lipids FEBS Lett, 2010
Proteolytic processing patterns of prosaposin in insect and mammalian cells J Biol Chem, 1996