Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PANK4 hydrolyzes PPANT to pantetheine

PPANT + H2O → Pantetheine + Pi

Reactome: R-HSA-9837419
Compartment: cytosol
Rhea: RHEA:68329

Inputs

PPANTCHEBI:61723, C11H21N2O7PS, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

PantetheineCHEBI:16753, C11H22N2O4S, cytosol
PiCHEBI:43474, HO4P, cytosol

Catalysed by

phosphatase activity of PANK4 [cytosol]EC 3.1.3; UniProt Q9NVE7

Literature

A family of metal-dependent phosphatases implicated in metabolite damage-control Nat Chem Biol, 2016
Regulation of coenzyme A levels by degradation: the 'Ins and Outs' Prog Lipid Res, 2020