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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NUDT8 hydrolyzes CoA-SH to PPANT

CoA-SH + H2O → 2 H+ + PAP + PPANT

Reactome: R-HSA-9837354
Compartment: mitochondrial matrix
Rhea: RHEA:64989

Inputs

CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
H2OCHEBI:15377, H2O, mitochondrial matrix

Outputs

2 H+CHEBI:15378, H, mitochondrial matrix
PAPCHEBI:58343, C10H11N5O10P2, mitochondrial matrix
PPANTCHEBI:61723, C11H21N2O7PS, mitochondrial matrix

Catalysed by

coenzyme A diphosphatase activity of NUDT8 [mitochondrial matrix]EC 3.6.1.77; UniProt Q8WV74

Literature

Nudt8 is a novel CoA diphosphohydrolase that resides in the mitochondria FEBS Lett, 2019