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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP

ADP + CoA-SH → ADP + CoA-SH

Reactome: R-HSA-9837333
Compartment: cytosol · mitochondrial matrix
Rhea: RHEA:72839

Inputs

ADPCHEBI:456216, C10H12N5O10P2, mitochondrial matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol

Outputs

ADPCHEBI:456216, C10H12N5O10P2, cytosol
CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix

Catalysed by

coenzyme A transmembrane transporter activity of SLC25A42 [mitochondrial inner membrane]UniProt Q86VD7

Literature

Inherited Disorders of Coenzyme A Biosynthesis: Models, Mechanisms, and Treatments Int J Mol Sci, 2023
A novel member of solute carrier family 25 (SLC25A42) is a transporter of coenzyme A and adenosine 3',5'-diphosphate in human mitochondria J Biol Chem, 2009