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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

AKR1E2 reduces 1,5-aF to 1,5-aG

1,5-aF + H+ + NADPH → 1,5-aG + NADP+

Reactome: R-HSA-9773976
Compartment: cytosol
Rhea: RHEA:20667

Inputs

1,5-aFCHEBI:16715, C6H10O5, cytosol
H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol

Outputs

1,5-aGCHEBI:16070, C6H12O5, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Catalysed by

1,5-anhydro-D-fructose reductase activity of AKR1E2 [cytosol]EC 1.1.1.263; UniProt Q96JD6

Literature

Characterization of htAKR, a novel gene product in the aldo-keto reductase family specifically expressed in human testis Mol Hum Reprod, 2004
Hepatic production of 1,5-anhydrofructose and 1,5-anhydroglucitol in rat by the third glycogenolytic pathway Eur J Biochem, 1996
Human testis specific protein: a new member of aldo-keto reductase superfamily Chem Biol Interact, 2003
Mouse AKR1E1 is an ortholog of pig liver NADPH dependent 1,5-anhydro-D-fructose reductase Biosci Biotechnol Biochem, 2008
Purification and some properties of a hepatic NADPH-dependent reductase that specifically acts on 1,5-anhydro-D-fructose J Biochem, 1998
A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2 Nat Metab, 2022