Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin

2 MMACHC:cob(I)alamin + H+ + NAD+ → 2 MMACHC:cob(II)alamin + NADH

Reactome: R-HSA-9759549
Compartment: cytosol
Rhea: RHEA:17482

Inputs

2 MMACHC:cob(I)alaminR-HSA-9759561, cytosol
H+CHEBI:15378, H, cytosol
NAD+CHEBI:57540, C21H26N7O14P2, cytosol

Outputs

2 MMACHC:cob(II)alaminR-HSA-3095903, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol

Catalysed by

oxidoreductase activity of Protein [cytosol]EC 1

Literature

Redox-Linked Coordination Chemistry Directs Vitamin B 12 Trafficking Acc Chem Res, 2021
Enzymatic conversion of vitamin B 12a to adenosyl-B 12: evidence for the existence of two separate reducing systems Arch Biochem Biophys, 1969