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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

LRP2-mediated TCN2:RCbl uptake and delivery to lysosome

LRP2:LDLRAP1:TCN2:RCbl → TCN2:RCbl + LRP2:LDLRAP1

Reactome: R-HSA-9759202
Compartment: lysosomal lumen · plasma membrane
Rhea: None recorded

Inputs

LRP2:LDLRAP1:TCN2:RCblR-HSA-9759208, plasma membrane

Outputs

TCN2:RCblR-HSA-3000242, lysosomal lumen
LRP2:LDLRAP1R-HSA-9759635, plasma membrane

Catalysed by

cargo receptor activity of LRP2:LDLRAP1:TCN2:RCbl [plasma membrane]

Literature

Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties Eur J Biochem, 1996
Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin J Biol Chem, 1995
Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis Proc Natl Acad Sci U S A, 1996
The adaptor protein ARH escorts megalin to and through endosomes Mol Biol Cell, 2003
ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression J Cell Biol, 2013