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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SPHK2 phosphorylates sphingoid

ATP + SPG → ADP + H+ + S1P

Reactome: R-HSA-9695949
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:51496

Inputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
SPGCHEBI:84410, C3H9NO2R, cytosol

Outputs

ADPCHEBI:456216, C10H12N5O10P2, cytosol
H+CHEBI:15378, H, cytosol
S1PCHEBI:76941, C3H8NO5PR, cytoplasm

Catalysed by

lipid kinase activity of SPHK2 [cytosol]UniProt Q9NRA0

Literature

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform J Biol Chem, 2000
SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism J. Biol. Chem., 2005
Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget Oncotarget, 2017
The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism Crit Rev Biochem Mol Biol, 2011