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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SPHK2 binds SPHK2 inhibitors

SPHK2 + SPHK2 inhibitors → SPHK2:SPHK2 inhibitors

Reactome: R-HSA-9695917
Compartment: cytosol
Rhea: None recorded

Inputs

SPHK2R-HSA-428236, cytosol
SPHK2 inhibitorsR-ALL-9695954, cytosol

Outputs

SPHK2:SPHK2 inhibitorsR-HSA-9695910, cytosol

Literature

Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2 J. Pharmacol. Exp. Ther., 2010
Characterization of isoenzyme-selective inhibitors of human sphingosine kinases PLoS ONE, 2012
(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: Effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells Cell. Signal., 2011
A selective ATP-competitive sphingosine kinase inhibitor demonstrates anti-cancer properties Oncotarget, 2015
Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity J. Med. Chem., 2020
Emerging Connections of S1P-Metabolizing Enzymes with Host Defense and Immunity During Virus Infections Viruses, 2019