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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SPNS2,MFSD2B transport S1P from cytosol to extracellular region

S1P → S1P

Reactome: R-HSA-9695890
Compartment: cytosol · extracellular region · plasma membrane
Rhea: None recorded

Inputs

S1PCHEBI:76941, C3H8NO5PR, cytoplasm

Outputs

S1PCHEBI:76941, C3H8NO5PR, extracellular region

Catalysed by

sphingolipid intramembrane carrier activity of SPNS2,MFSD2B [plasma membrane]

Literature

Spns2, a transporter of phosphorylated sphingoid bases, regulates their blood and lymph levels, and the lymphatic network FASEB J., 2013
New insights into functions of the sphingosine-1-phosphate transporter SPNS2 J Lipid Res, 2019
Structural and functional insights into Spns2-mediated transport of sphingosine-1-phosphate Cell, 2023
An erythrocyte-centric view on the MFSD2B sphingosine-1-phosphate transporter Pharmacol Ther, 2023
MFSD2B is a sphingosine 1-phosphate transporter in erythroid cells Sci Rep, 2018