Bacterial GUSB hydrolyses BDG to BIL
BDG + 3 NADPH + 2 H2O → 3 NADP+ + 2 GlcA + BIL
- Reactome
- R-HSA-9661820
- Compartment
- extracellular region
- Rhea
- None recorded
Inputs
- BDGCHEBI:58471, C45H50N4O18, extracellular region
- 3 NADPHCHEBI:16474, C21H30N7O17P3, extracellular region
- 2 H2OCHEBI:15377, H2O, extracellular region
Outputs
- 3 NADP+CHEBI:18009, C21H29N7O17P3, extracellular region
- 2 GlcACHEBI:15748, C6H9O7, extracellular region
- BILCHEBI:57977, C33H34N4O6, extracellular region
Catalysed by
- hydrolase activity, hydrolyzing O-glycosyl compounds of GUSB [extracellular region]EC 3.2.1; UniProt Q8VNV4
Literature
- Purification and characterization of beta-glucuronidase from Escherichia coli HGU-3, a human intestinal bacterium Biol. Pharm. Bull., 1995
- Expression of bacterial beta-glucuronidase in human bile: an in vitro study Gastrointest. Endosc., 2001
- [Bilirubin metabolism (author's transl)] Wien. Klin. Wochenschr., 1976