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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALB binds extracellular heme

ALB + heme → ALB:heme

Reactome: R-HSA-9661419
Compartment: extracellular region
Rhea: None recorded

Inputs

ALBR-HSA-194115, extracellular region
hemeCHEBI:60344, C34H30FeN4O4, extracellular region

Outputs

ALB:hemeR-HSA-9661451, extracellular region

Catalysed by

heme binding activity of ALB [extracellular region]UniProt P02768

Literature

Heme Scavenging and Delivery: The Role of Human Serum Albumin Biomolecules, 2023
ABCG2 transports and transfers heme to albumin through its large extracellular loop J. Biol. Chem., 2010