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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

FLVCR1-2 transports heme from mitochondrial matrix to cytosol

heme → ferroheme

Reactome: R-HSA-9661408
Compartment: cytosol · mitochondrial matrix · mitochondrial inner membrane
Rhea: RHEA:75443

Inputs

hemeCHEBI:60344, C34H30FeN4O4, mitochondrial matrix

Outputs

ferrohemeCHEBI:60344, C34H30FeN4O4, cytosol

Catalysed by

heme transmembrane transporter activity of FLVCR1-2 [mitochondrial inner membrane]UniProt Q9Y5Y0

Literature

The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation J. Clin. Invest., 2012