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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLCO1B1 transports BIL from extracellular region (blood) to cytosol (hepatocyte)

BIL → BIL

Reactome: R-HSA-9661397
Compartment: cytosol · extracellular region · plasma membrane
Rhea: None recorded

Inputs

BILCHEBI:57977, C33H34N4O6, extracellular region

Outputs

BILCHEBI:57977, C33H34N4O6, cytosol

Catalysed by

secondary active transmembrane transporter activity of SLCO1B1 [plasma membrane]UniProt Q9Y6L6

Literature

A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane Am J Physiol Gastrointest Liver Physiol, 2000
Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6 J. Biol. Chem., 2001