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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

HEXB cleaves the terminal GalNAc from DS

H2O + ChEBI:63516 chain → GalNAc + IdoA-GalNAc(4S)-GlcA-Gal-Gal-Xyl

Reactome: R-HSA-9638075
Compartment: lysosomal lumen
Rhea: None recorded

Inputs

H2OCHEBI:15377, H2O, lysosomal lumen
ChEBI:63516 chainCHEBI:747395, C45H69N2O40S, lysosomal lumen

Outputs

GalNAcCHEBI:28037, C8H15NO6, lysosomal lumen
IdoA-GalNAc(4S)-GlcA-Gal-Gal-XylCHEBI:63873, C37H59NO35S, lysosomal lumen

Catalysed by

beta-N-acetylhexosaminidase activity of bHEXB [lysosomal lumen]EC 3.2.1.52

Literature

Oligosaccharide structure and amino acid sequence of the major glycopeptides of mature human beta-hexosaminidase Biochemistry, 1988