CSGALNACTs transfer GalNAc to CS chain
chondroitin(2)-core proteins + UDP-GalNAc → UDP + chondroitin(3)-core proteins + H+
- Reactome
- R-HSA-9632033
- Compartment
- Golgi membrane · Golgi lumen
- Rhea
- None recorded
Inputs
- chondroitin(2)-core proteinsR-HSA-2064050, Golgi lumen
- UDP-GalNAcCHEBI:57847, C17H25N3O17P2, Golgi lumen
Outputs
- UDPCHEBI:58223, C9H11N2O12P2, Golgi lumen
- chondroitin(3)-core proteinsR-HSA-2064075, Golgi lumen
- H+CHEBI:15378, H, Golgi lumen
Catalysed by
- glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity of CSGALNACT [Golgi membrane]EC 2.4.1.175
Literature
- Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase: the key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate J Biol Chem, 2002
- Enzymatic synthesis of chondroitin with a novel chondroitin sulfate N-acetylgalactosaminyltransferase that transfers N-acetylgalactosamine to glucuronic acid in initiation and elongation of chondroitin sulfate synthesis J Biol Chem, 2002
- Chondroitin Sulfate N-acetylgalactosaminyltransferase-1 (CSGalNAcT-1) Deficiency Results in a Mild Skeletal Dysplasia and Joint Laxity Hum Mutat, 2017
- Biosynthesis and function of chondroitin sulfate Biochim Biophys Acta, 2013