Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Transfer of sulfur from MOCS3-S-S onto MOCS2A

MOCS2 + ATP + MOCS3-S-S(1-):Zn2+ → SOG-MOCS2 + AMP + PPi + MOCS3:Zn2+ (ox.)

Reactome: R-HSA-947538
Compartment: cytosol
Rhea: None recorded

Inputs

MOCS2R-HSA-947542, cytosol
ATPCHEBI:30616, C10H12N5O13P3, cytosol
MOCS3-S-S(1-):Zn2+R-HSA-947584, cytosol

Outputs

SOG-MOCS2R-HSA-947517, cytosol
AMPCHEBI:456215, C10H12N5O7P, cytosol
PPiCHEBI:33019, HO7P2, cytosol
MOCS3:Zn2+ (ox.)R-HSA-947568, cytosol

Catalysed by

sulfurtransferase activity of MOCS3-S-S(1-):Zn2+ [cytosol]EC 2.8.1

Literature

A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis J Biol Chem, 2008