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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Cyclisation of GTP to precursor Z

GTP + AdoMet + H2O → Precursor Z + PPi + L-Met + dADE

Reactome: R-HSA-947535
Compartment: cytosol
Rhea: None recorded

Inputs

GTPCHEBI:37565, C10H12N5O14P3, cytosol
AdoMetCHEBI:59789, C15H23N6O5S, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

Precursor ZCHEBI:59648, C10H11N5O7P, cytosol
PPiCHEBI:33019, HO7P2, cytosol
L-MetCHEBI:57844, C5H11NO2S, cytosol
dADECHEBI:17319, C10H13N5O3, cytosol

Catalysed by

S-adenosyl-L-methionine binding activity of holo-MOCS1 [cytosol]

Cyclisation of GTP to precursor Z

Inputs

Outputs

Catalysed by

Literature